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Article

Global analysis of genetic circuitry and adaptive mechanisms enabling resistance to the azole antifungal drugs.

PLoS genetics - 1 Apr 2018

Mount Harley O'Connor, Revie Nicole M, Todd Robert T, Anstett Kaitlin, Collins Cathy, Costanzo Michael, Boone Charles, Robbins Nicole, Selmecki Anna, Cowen Leah E

Abstract excerpt

Invasive fungal infections caused by the pathogen Candida albicans have transitioned from a rare curiosity to a major cause of human mortality. This is in part due to the emergence of resistance to the limited number of antifungals available to treat fungal infections. Azoles function by targeting the biosynthesis of ergosterol, a key component of the fungal cell membrane. Loss-of-function mutations in the...

Topics

Antifungal Agents
Azoles
Candida albicans
Drug Resistance, Fungal
GTPase-Activating Proteins
Host-Pathogen Interactions
Humans
Microbial Sensitivity Tests
Mutation
Mycoses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oxidoreductases

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Vesicular Transport Proteins

Whole Genome Sequencing

Source

Open in PubMed Open full text

Identifiers

PMID: 29702647
DOI: 10.1371/journal.pgen.1007319
PMCID: PMC5922528

Genes

NPR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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