Article

CRISPR-activation reveals key resistance genes and vulnerabilities of copy number variants in <i>Candida albicans</i>

2026-08-09

Abstract excerpt

<h4>ABSTRACT</h4> Changes in gene copy number are an extremely important source of variation and are frequently observed during the acquisition of drug resistance. The opportunistic human fungal pathogen Candida albicans frequently adapts to antifungal drugs via large copy number variations (CNVs) that amplify hundreds of genes simultaneously. Despite the recurrent amplification of CNVs across diverse clinical i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 470ea468-09fe-57ea-84ec-3ed9688484f1
DOI: 10.64898/2026.08.07.743545

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CRISPR-activation reveals key resistance genes and vulnerabilities of copy number variants in <i>Candida albicans</i>DOI 10.64898/2026.08.07.743545Read

Pooled CRISPRi screening reveals fungal-specific vulnerabilities across environments and genetic backgroundsSemantic proximity Read

Pooled CRISPRi screening reveals fungal-specific vulnerabilities across environments and genetic backgroundsSemantic proximity Read

Single-cell detection of copy number changes reveals dynamic mechanisms of adaptation to antifungals in Candida albicans.Semantic proximity Read

HyperdCas12a-Based Multiplexed Genetic Regulation in <i>Candida albicans</i>Semantic proximity Read

Development and applications of a CRISPR activation system for facile genetic overexpression in Candida albicansSemantic proximity Read

A high aneuploidy supply rate underlies parallel evolution of fluconazole resistance in <i>Saccharomyces cerevisiae</i>Semantic proximity Read

Identification of essential genes and fluconazole resistance genes in <i>Candida glabrata</i> by profiling of <i>Hermes</i> transposon insertionsSemantic proximity Read

Targeted loss of heterozygosity in <i>Candida albicans</i> using CRISPR-Cas9Semantic proximity Read

Rapid Hypothesis Testing in Candida albicans Clinical Isolates Using a Cloning-Free, Modular, and Recyclable System for CRISPR-Cas9 Mediated Mutant and Revertant ConstructionSemantic proximity Read

Haploinsufficiency-based large-scale forward genetic analysis of filamentous growth in the diploid human fungal pathogen C.albicans.Semantic proximity Read

MAESTRO uncovers tandem paralog dynamics as a core driver of fungal stress adaptationSemantic proximity Read

Recreation of in-host acquired single nucleotide polymorphisms by CRISPR-Cas9 reveals an uncharacterised gene playing a role in Aspergillus fumigatus azole resistance via a non-cyp51A mediated resistance mechanismSemantic proximity Read