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Article

Brain microvascular endothelial cell dysfunction in an isogenic juvenile iPSC model of Huntington’s disease

2021-09-22

Abstract excerpt

<title>Abstract</title> <p>Huntington’s disease (HD) is an inherited neurodegenerative disease caused by expansion of cytosine–adenine–guanine (CAG) repeats in the huntingtin gene, which leads to neuronal loss and decline in cognitive and motor function. Increasing evidence suggests that blood-brain barrier (BBB) dysfunction may contribute to progression of the disease. Studies in animal models, <italic>in vitro<...

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Literature Corpus work
2104f6e7-0b45-5cc0-9f8e-300ec2a022e4
DOI
10.21203/rs.3.rs-903286/v1
Open publication

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Brain microvascular endothelial cell dysfunction in an isogenic juvenile iPSC model of Huntington’s diseaseDOI 10.21203/rs.3.rs-903286/v1
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