miRNA family miR-29 inhibits PINK1-PRKN dependent mitophagy via ATG9A

Abstract excerpt

<h4>ABSTRACT</h4> Loss-of-function mutations in the genes encoding PINK1 and PRKN result in early-onset Parkinson disease (EOPD). Together the encoded enzymes direct a neuroprotective pathway that ensures the elimination of damaged mitochondria via autophagy. We performed a genome-wide high content imaging miRNA screen for inhibitors of the PINK1-PRKN pathway and identified all three members of the miRNA family 2...

Topics

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• Autophagy in Disease and Therapy
• Glycine
• Lysosomal Storage Disorders Research
• Metabolic Networks and Pathways
• Mitochondrial Membranes
• Mitochondrial Proteins
• Nuclear Receptors and Signaling
• Parkinson's Disease Mechanisms and Treatments

Identifiers and source

Literature Corpus work

e6393a42-207b-5dc7-bd64-56f402aaa8cb

DOI

10.1101/2024.01.17.576122