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Systematic Functional Analysis of PINK1 and PRKN Coding Variants

5 Aug 2022

Abstract excerpt

Loss of either PINK1 or PRKN causes an early onset Parkinson’s disease (PD) phenotype. Functionally, PINK1 and PRKN work together to mediate stress-activated mitochondrial quality control. Upon mitochondrial damage, PINK1, a ubiquitin kinase and PRKN, a ubiquitin ligase, decorate damaged organelles with phosphorylated ubiquitin for sequestration and degradation in lysosomes, a process known as mitophagy. While...

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PMID: 35954270
DOI: 10.3390/cells11152426

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