<i>CircEPS15</i>, as a sponge of <i>MIR24-3p</i> ameliorates neuronal damage in Parkinson disease through boosting PINK1-PRKN-mediated mitophagy

Abstract excerpt

Despite growing evidence that has declared the importance of circRNAs in neurodegenerative diseases, the clinical significance of circRNAs in dopaminergic (DA) neuronal degeneration in the pathogenesis of Parkinson disease (PD) remains unclear. Here, we performed rRNA-depleted RNA sequencing and detected more than 10,000 circRNAs in the plasma samples of PD patients. In consideration of ROC and the correlation...

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