Article

Kinome screening identifies integrated stress response kinase EIF2AK1 / HRI as a negative regulator of PINK1 mitophagy signaling

2023-03-22

Abstract excerpt

<h4>ABSTRACT</h4> Loss-of-function mutations of the PINK1 kinase cause familial early-onset Parkinson’s disease (PD). PINK1 is activated upon mitochondrial damage to phosphorylate Ubiquitin and Parkin to trigger removal of damaged mitochondria by autophagy (mitophagy). PINK1 also indirectly phosphorylates a subset of Rab GTPases including Rab8A. We have performed an siRNA screen targeting all human Ser/Thr kinase...

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Literature Corpus work: 0eb22a2f-f439-58cf-bbff-986a5ba33ffb
DOI: 10.1101/2023.03.20.533516

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