Article

High-content phenotypic screen to identify small molecule enhancers of Parkin-dependent ubiquitination and mitophagy

2022-10-01

Abstract excerpt

<h4>ABSTRACT</h4> Mitochondrial dysfunction and aberrant mitochondrial homeostasis are key aspects of Parkinson’s disease (PD) pathophysiology. Mutations in PINK1 and Parkin proteins lead to autosomal recessive PD, suggesting that defective mitochondrial clearance via mitophagy is key in PD etiology. Accelerating the identification and/or removal of dysfunctional mitochondria could therefore provide a disease-mod...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 98bf37c6-765b-5dd0-9524-ac904953bad6
DOI: 10.1101/2022.09.30.509127

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

High-content phenotypic screen to identify small molecule enhancers of Parkin-dependent ubiquitination and mitophagyDOI 10.1101/2022.09.30.509127Read

High-content phenotypic screen to identify small molecule enhancers of Parkin-dependent ubiquitination and mitophagy.Semantic proximity Read

Investigation of USP30 inhibition to enhance Parkin-mediated mitophagy: tools and approachesSemantic proximity Read

Targeting mitophagy in Parkinson's disease.Semantic proximity Read

Therapeutic approaches to enhance PINK1/Parkin mediated mitophagy for the treatment of Parkinson’s diseaseSemantic proximity Read

Benchmarking a highly selective USP30 inhibitor for enhancement of mitophagy and pexophagySemantic proximity Read

Pharmacological PINK1 activation ameliorates Pathology in Parkinson’s Disease modelsSemantic proximity Read

A CRISPR-CAS9 high throughput machine-learning platform for modulation of genes involved in Parkinson’s disease-associated PINK1-mitophagy in iPSC-derived dopaminergic neuronsSemantic proximity Read

Pharmacological PINK1 activation ameliorates Pathology in Parkinson’s Disease modelsSemantic proximity Read

A novel USP30 inhibitor recapitulates genetic loss of USP30 and sets the trigger for PINK1-PARKIN amplification of mitochondrial ubiquitylationSemantic proximity Read

Parkin-linked Parkinson's disease: From clinical insights to pathogenic mechanisms and novel therapeutic approaches.Semantic proximity Read

Mitochondria-affecting small molecules ameliorate proteostasis defects associated with neurodegenerative diseasesSemantic proximity Read

USP30 inhibition improves mitochondrial health through both PINK1-dependent and independent mechanismsSemantic proximity Read