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Article

Genome-wide RNAi screen identifies the Parkinson disease GWAS risk locus <i>SREBF1</i> as a regulator of mitophagy

27 May 2014

Abstract excerpt

Genetic analysis of Parkinson disease (PD) has identified several genes whose mutation causes inherited parkinsonism, as well as risk loci for sporadic PD. PTEN-induced kinase 1 (PINK1) and parkin, linked to autosomal recessive PD, act in a common genetic pathway regulating the autophagic degradation of mitochondria, termed mitophagy. We undertook a genome-wide RNAi screen as an unbiased approach to identify...

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PMID: 24912190
DOI: 10.1073/pnas.1321207111

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