Article

Defects in Mitochondrial Biogenesis Drive Mitochondrial Alterations in PINK1-deficient Human Dopamine Neurons

2023-06-26

Abstract excerpt

<h4>Summary</h4> Mutations and loss of activity in the protein kinase PINK1 play a role in the pathogenesis of Parkinson’s disease (PD). PINK1 regulates many aspects of mitochondrial quality control including mitochondrial autophagy (mitophagy), fission, fusion, transport, and biogenesis. Defects in mitophagy are though to play a predominant role in the loss of dopamine (DA) neurons in PD. Here we show that, alth...

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Literature Corpus work: 8eb85d02-3183-55be-a1b4-56edad3cb350
DOI: 10.1101/2023.06.23.546087

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