USP30 inhibition improves mitochondrial health through both PINK1-dependent and independent mechanisms

Abstract excerpt

Mitochondrial dysfunction is a key feature of many pathologies, including Parkinson’s disease. The selective vulnerability of dopaminergic neurons is thought to be influenced by mitochondrial dysfunction and mutations in the mitophagy regulating proteins PINK1 and Parkin that are known to cause early-onset Parkinsonism in an autosomal recessive manner. Augmentation of mitophagy through inhibition of USP30 may be a...

Topics

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• Antiparkinson Agents
• Autophagy in Disease and Therapy
• Drug Discovery
• Mitochondria
• Mitophagy
• Mutation
• Parkinson Disease
• Parkinson's Disease Mechanisms and Treatments

Identifiers and source

Literature Corpus work

b1370cd7-2ce8-5237-bfee-e906a8071337

DOI

10.1101/2025.02.03.636341