Distinct age- and pathology-dependent epitranscriptome and translational dysfunction in a tauopathy mouse model

Abstract excerpt

Chronic neurodegenerative diseases, such as tauopathies, cause major metabolic changes in the brain affecting gene expression at both the transcriptional and translational levels. Our understanding of how regulation of translation changes with disease has focused on mRNA and its translational regulatory factors, RNA binding proteins, and microRNAs, despite clear evidence for translational and post-translational dy...

Topics

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• Evolution, Molecular
• Genetic Diseases, Inborn
• Models, Molecular
• Nucleic Acid Conformation
• Protein Biosynthesis
• RNA and protein synthesis mechanisms
• RNA modifications and cancer
• RNA, Transfer

Identifiers and source

Literature Corpus work

e623baac-2032-52e3-b52b-25b9e8ee9e76

DOI

10.1101/2025.05.15.654371