Evolutionarily Conserved Decline of tRNA Mannosyl-Queuosine Links Translational Regulation to Aging and Is Reversed by Queuine

Abstract excerpt

Aging arises from interconnected molecular defects, yet upstream regulatory mechanisms that coordinate these hallmarks remain incompletely defined. While epitranscriptomic regulation has emerged as a critical layer of gene control, the contribution of tRNA-specific modifications to aging remains largely unexplored. Here, we systematically profile tRNA modifications across multiple organs, species, and senescence m...

Topics

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• Adenosine
• Cell Differentiation
• Gene Expression Regulation, Developmental
• Mice
• Mouse Embryonic Stem Cells
• Peptidase Inhibition and Analysis
• RNA and protein synthesis mechanisms
• RNA modifications and cancer

Identifiers and source

Literature Corpus work

b0e0ef6b-add3-5a1b-a89a-07f49257f21a

DOI

10.64898/2026.03.22.713446