Translation dysregulation in neurodegenerative diseases: a focus on ALS

Abstract excerpt

RNA translation is tightly controlled in eukaryotic cells to regulate gene expression and maintain proteome homeostasis. RNA binding proteins, translation factors, and cell signaling pathways all modulate the translation process. Defective translation is involved in multiple neurological diseases including amyotrophic lateral sclerosis (ALS). ALS is a progressive neurodegenerative disorder and poses a major...

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• Amyotrophic Lateral Sclerosis Research
• Neurogenetic and Muscular Disorders Research
• RNA Research and Splicing