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Article

TAp73 contributes to the oxidative stress response by regulating protein synthesis

29 May 2018

Abstract excerpt

TAp73 is a transcription factor that plays key roles in brain development, aging, and cancer. At the cellular level, TAp73 is a critical homeostasis-maintaining factor, particularly following oxidative stress. Although major studies focused on TAp73 transcriptional activities have indicated a contribution of TAp73 to cellular metabolism, the mechanisms underlying its role in redox homeostasis have not been...

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PMID: 29844156
DOI: 10.1073/pnas.1718531115

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