Mitochondrial tRNA modifications: functions, diseases caused by their loss, and treatment strategies.

doi:10.1261/rna.080257.124

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Mitochondrial tRNA modifications: functions, diseases caused by their loss, and treatment strategies.

RNA (New York, N.Y.) - 19 Feb 2025

Chujo Takeshi, Tomizawa Kazuhito

Abstract excerpt

Mitochondrial tRNA (mt-tRNA) modifications play pivotal roles in decoding and sustaining tRNA stability, thereby enabling the synthesis of essential respiratory complex proteins in mitochondria. Consequently, loss of human mt-tRNA modifications caused by mutations in the mitochondrial or nuclear genome can cause life-threatening mitochondrial diseases such as encephalopathy and cardiomyopathy. In this article, we...

Topics

Humans
RNA, Transfer
Mitochondrial Diseases
Mitochondria
RNA Processing, Post-Transcriptional
RNA, Mitochondrial
Mutation
DNA, Mitochondrial
MELAS Syndrome

Source

Open in PubMed Open full text

Identifiers

PMID: 39719325
DOI: 10.1261/rna.080257.124
PMCID: PMC11874988

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics