Article

Cell-type specific impact of opioid use disorder and HIV on the human forebrain and cerebellum

2026-03-03

Abstract excerpt

Opioid use disorder (OUD), which frequently co-occurs with HIV infection, causes long-term neurological disease, yet the epigenetic and transcriptomic effects of OUD and HIV on specific cell types and regions of the brain are poorly understood. To assess the cell-type specific impacts of OUD and HIV across the human brain, we measured single cell transcriptomes and epigenomes of 580,353 cells in the prefrontal cor...

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Literature Corpus work: e60d0919-0e0a-5487-82a5-cfd5991d4dc6
DOI: 10.64898/2026.03.01.708876

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