Article

Persistent large-scale changes in alternative splicing in prefrontal cortical neuron types following psychedelic exposure

2025-01-16

Abstract excerpt

<h4>Summary</h4> Psychedelics engage the serotonergic system as potent neuromodulators, increasing neuroplasticity in humans and rodents. Persistent changes in cognitive flexibility, emotional regulation, and social cognition are thought to underlie the therapeutic effects of psychedelics. However, the underlying molecular and cellular basis of psychedelic-induced plasticity remains unclear. Here, we identify per...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a37d88cf-4897-5f65-97f9-e9bf400b1941
DOI: 10.1101/2025.01.16.633439

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Persistent large-scale changes in alternative splicing in prefrontal cortical neuron types following psychedelic exposureDOI 10.1101/2025.01.16.633439Read

Cross-species mapping of psychedelic gene expression reveals links to the 5HT2A receptor, cortical layers, and human accelerated regionsSemantic proximity Read

Prolonged epigenetic and synaptic plasticity alterations following single exposure to a psychedelic in miceSemantic proximity Read

Cell-type specific impact of opioid use disorder and HIV on the human forebrain and cerebellumSemantic proximity Read

Psilocybin Promotes Cell-Type-Specific Changes in the Orbitofrontal Cortex Revealed by Single-Nucleus RNA-seqSemantic proximity Read

Functional genomic mechanisms of opioid action and opioid use disorder: a systematic review of animal models and human studiesSemantic proximity Read

Cell-Type Specific Profiling of Histone Post-Translational Modifications in the Adult Mouse StriatumSemantic proximity Read

Microendophenotypes of psychiatric disorders: phenotypes of psychiatric disorders at the level of molecular dynamics, synapses, neurons, and neural circuits.Semantic proximity Read

Integrative multiomics profiling of cortical brain organoids reveals a druggable alternative splicing program in schizophreniaSemantic proximity Read

Discrete prefrontal neuronal circuits determine repeated stress-induced behavioral phenotypes in male mice.Semantic proximity Read

An emerging multi-omic understanding of the genetics of opioid addictionSemantic proximity Read

Medicine. The future of psychiatric research: genomes and neural circuits.Semantic proximity Read

Methamphetamine induced regional-specific transcriptomic and epigenetic changes in the rat brainSemantic proximity Read