Article

Single Nucleus Transcriptomics Reveals Pervasive Glial Activation in Opioid Overdose Cases

2023-03-09

Abstract excerpt

<h4>ABSTRACT</h4> Dynamic interactions of neurons and glia in the ventral midbrain (VM) mediate reward and addiction behavior. We studied gene expression in 212,713 VM single nuclei from 95 human opioid overdose cases and drug-free controls. Chronic exposure to opioids left numerical proportions of VM glial and neuronal subtypes unaltered, while broadly affecting glial transcriptomes, involving 9.5 - 6.2% of expr...

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Literature Corpus work: f5aaf23b-2fd7-57a9-9867-4e7e32a7d920
DOI: 10.1101/2023.03.07.531400

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