Article

The integrated stress response regulates BMP signaling through effects on translation

2018-02-15

Abstract excerpt

Developmental pathways must be responsive to the environment. Phosphorylation of eIF2α enables a family of stress sensing kinases to trigger the integrated stress response (ISR), which has pro-survival and developmental consequences. Mutations of the ISR kinase GCN2 have been implicated in the development of pulmonary arterial hypertension, a disorder known to be associated with defects of BMP signaling, but how t...

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Literature Corpus work: e5e304a2-934f-517b-b6e7-649425f027f4
DOI: 10.1101/266189

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