Article
Pin1-mediated Runx2 modification is critical for skeletal development.
Journal of cellular physiology - 1 Dec 2013
Yoon Won-Joon, Islam Rabia, Cho Young-Dan, Woo Kyung-Mi, Baek Jeong-Hwa, Uchida Takafumi, Komori Toshihisa, van Wijnen Andre, Stein Janet L, Lian Jane B, Stein Gary S, Choi Je-Yong, Bae Suk-Chul, Ryoo Hyun-Mo
Abstract excerpt
Runx2 is the master transcription factor for bone formation. Haploinsufficiency of RUNX2 is the genetic cause of cleidocranial dysplasia (CCD) that is characterized by hypoplastic clavicles and open fontanels. In this study, we found that Pin1, peptidyl prolyl cis-trans isomerase, is a critical regulator of Runx2 in vivo and in vitro. Pin1 mutant mice developed CCD-like phenotypes with hypoplastic clavicles and...
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