Article

Reversal of pulmonary veno-occlusive disease phenotypes by inhibition of the integrated stress response

2023-11-28

Abstract excerpt

Pulmonary veno-occlusive disease (PVOD) is a rare form of pulmonary hypertension arising from EIF2AK4 gene mutations or mitomycin C (MMC) administration. The lack of effective PVOD therapies is compounded by a limited understanding of the mechanisms driving the vascular remodeling in PVOD. We show that the administration of MMC in rats mediates the activation of protein kinase R (PKR) and the integrated stress res...

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Literature Corpus work: 0e63d3d6-d3b9-5c42-861f-0796f4f58563
DOI: 10.1101/2023.11.27.568924

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