Article
Inhibiting the integrated stress response pathway prevents aberrant chondrocyte differentiation thereby alleviating chondrodysplasia.
eLife - 19 Jul 2018
Wang Cheng, Tan Zhijia, Niu Ben, Tsang Kwok Yeung, Tai Andrew, Chan Wilson C W, Lo Rebecca L K, Leung Keith K H, Dung Nelson W F, Itoh Nobuyuki, Zhang Michael Q, Chan Danny, Cheah Kathryn Song Eng
Abstract excerpt
The integrated stress response (ISR) is activated by diverse forms of cellular stress, including endoplasmic reticulum (ER) stress, and is associated with diseases. However, the molecular mechanism(s) whereby the ISR impacts on differentiation is incompletely understood. Here, we exploited a mouse model of Metaphyseal Chondrodysplasia type Schmid (MCDS) to provide insight into the impact of the ISR on cell fate....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.