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Article

Phosphorylation by the DHIPK2 protein kinase modulates the corepressor activity of Groucho.

The Journal of biological chemistry - 3 Jun 2005

Choi Cheol Yong, Kim Young Ho, Kim Yong-Ou, Park Sang Joon, Kim Eun-A, Riemenschneider William, Gajewski Kathleen, Schulz Robert A, Kim Yongsok

Abstract excerpt

Groucho function is essential for Drosophila development, acting as a corepressor for specific transcription factors that are downstream targets of various signaling pathways. Here we provide evidence that Groucho is phosphorylated by the DHIPK2 protein kinase. Phosphorylation modulates Groucho corepressor activity by attenuating its protein-protein interaction with a DNA-bound transcription factor. During eye...

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Identifiers

PMID: 15802274
DOI: 10.1074/jbc.M500496200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Phosphorylation by the DHIPK2 protein kinase modulates the corepressor activity of Groucho.PMID 15802274Read ↗

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