Article

Functional interrogation of candidate <i>cis</i> -regulatory elements at the <i>LDLR</i> locus

2025-03-24

Abstract excerpt

<h4>ABSTRACT</h4> Regulation of LDLR gene expression plays an important role in the development of atherosclerotic diseases including heart attack and stroke. Although LDLR regulation by sterol response elements has been well characterized, the functional significance of other noncoding regions at the LDLR locus remains poorly defined. We developed and applied a high throughput CRISPR screen to test the functi...

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Literature Corpus work: e5d06510-c8dc-5cbd-811b-aa7388cc2bd9
DOI: 10.1101/2025.03.20.644385

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