Article

Systematic elucidation of genetic mechanisms underlying cholesterol uptake

2023-01-10

Abstract excerpt

<h4>Summary</h4> Genetic variation contributes greatly to LDL cholesterol (LDL-C) levels and coronary artery disease risk. By combining analysis of rare coding variants from the UK Biobank and genome-scale CRISPR-Cas9 knockout and activation screening, we have substantially improved the identification of genes whose disruption alters serum LDL-C levels. We identify 21 genes in which rare coding variants significa...

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Literature Corpus work: e6c7d8c5-db1b-5c4f-91e2-f437022c3e86
DOI: 10.1101/2023.01.09.500804

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