Article

Functional interrogation of cellular Lp(a) uptake by genome-scale CRISPR screening

2024-05-12

Abstract excerpt

<h4>ABSTRACT</h4> An elevated level of lipoprotein(a), or Lp(a), in the bloodstream has been causally linked to the development of atherosclerotic cardiovascular disease and calcific aortic valve stenosis. Steady state levels of circulating lipoproteins are modulated by their rate of clearance, but the identity of the Lp(a) uptake receptor(s) has been controversial. In this study, we performed a genome-scale CRIS...

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Literature Corpus work: 7df86885-f978-5152-ab61-a81dfb130439
DOI: 10.1101/2024.05.11.593568

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