Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional genomics and assays of regulatory activity detect mechanisms at loci for lipid traits and coronary artery disease.

Current opinion in genetics & development - 1 Jun 2018

Roman Tamara S, Mohlke Karen L

Abstract excerpt

Many genome-wide association studies (GWAS) have identified signals located in non-coding regions, and an increasing number of functional genomics annotations of regulatory elements and assays of regulatory activity have been used to investigate mechanisms. Genome-wide datasets that characterize chromatin structure help detect potential regulatory elements. Assays to experimentally assess candidate variants...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Coronary Artery Disease
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome, Human

Share to Genome-Wide Association Study

Share to Genomics

Share to Lipids

Share to Quantitative Trait Loci

Source

Open in PubMed Open full text

Identifiers

PMID: 29471259
DOI: 10.1016/j.gde.2018.02.004
PMCID: PMC6089635

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional genomics and assays of regulatory activity detect mechanisms at loci for lipid traits and coronary artery disease.PMID 29471259Read ↗

High-Throughput Screening and CRISPR-Cas9 Modeling of Causal Lipid-Associated Expression Quantitative Trait Locus VariantsSemantic proximity Read ↗

Functional interrogation of candidate <i>cis</i> -regulatory elements at the <i>LDLR</i> locusSemantic proximity Read ↗

Integrative analysis of liver-specific non-coding regulatory SNPs associated with the risk of coronary artery disease.Semantic proximity Read ↗

Systematic identification of human SNPs affecting regulatory element activitySemantic proximity Read ↗

Comprehensive identification of coronary artery disease-associated variants regulating vascular smooth muscle cell gene expressionSemantic proximity Read ↗

Emerging applications of genome-editing technology to examine functionality of GWAS-associated variants for complex traits.Semantic proximity Read ↗

Enhancer scanning to locate regulatory regions in genomic loci.Semantic proximity Read ↗

Direct characterization of cis-regulatory elements and functional dissection of complex genetic associations using HCR-FlowFISH.Semantic proximity Read ↗

High-throughput identification methods of genomic functional variation in post-GWAS era and their application in agricultural animals.Semantic proximity Read ↗

[Strategies for elucidating functional significance of complex disease related loci].Semantic proximity Read ↗

Screening for functional transcriptional and splicing regulatory variants with GenIE.Semantic proximity Read ↗

A new era in functional genomics screens.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.