Article

Genome-scale CRISPR screening for modifiers of cellular LDL uptake

2020-07-01

Abstract excerpt

<h4>ABSTRACT</h4> Hypercholesterolemia is a causal and modifiable risk factor for atherosclerotic cardiovascular disease. A critical pathway regulating cholesterol homeostasis involves the receptor-mediated endocytosis of low-density lipoproteins into hepatocytes, mediated by the LDL receptor. We applied genome-scale CRISPR screening to query the genetic determinants of cellular LDL uptake in HuH7 cells cultured...

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Literature Corpus work: 182c483a-d984-5bc8-b2a2-74fba9a27477
DOI: 10.1101/2020.07.01.182246

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