Integrative analysis of liver-specific non-coding regulatory SNPs associated with the risk of coronary artery disease.

doi:10.1016/j.ajhg.2021.02.006

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Article

Integrative analysis of liver-specific non-coding regulatory SNPs associated with the risk of coronary artery disease.

American journal of human genetics - 4 Mar 2021

Selvarajan Ilakya, Toropainen Anu, Garske Kristina M, López Rodríguez Maykel, Ko Arthur, Miao Zong, Kaminska Dorota, Õunap Kadri, Örd Tiit, Ravindran Aarthi, Liu Oscar H, Moreau Pierre R, Jawahar Deen Ashik, Männistö Ville, Pan Calvin, Levonen Anna-Liisa, Lusis Aldons J, Heikkinen Sami, Romanoski Casey E, Pihlajamäki Jussi, Pajukanta Päivi, Kaikkonen Minna U

Abstract excerpt

Genetic factors underlying coronary artery disease (CAD) have been widely studied using genome-wide association studies (GWASs). However, the functional understanding of the CAD loci has been limited by the fact that a majority of GWAS variants are located within non-coding regions with no functional role. High cholesterol and dysregulation of the liver metabolism such as non-alcoholic fatty liver disease confer...

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PMID: 33626337
DOI: 10.1016/j.ajhg.2021.02.006
PMCID: PMC8008493

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