Article

Regulation of cellular LDL uptake by <i>PROX1</i> and <i>CHD7</i>

2022-09-20

Abstract excerpt

An elevated level of low-density lipoprotein (LDL) in the bloodstream is a causal risk factor for atherosclerotic cardiovascular disease (ASCVD). The low-density lipoprotein receptor (LDLR) is a critical regulator of circulating LDL, and increasing LDLR activity is an effective therapeutic approach to reduce circulating LDL cholesterol levels. In this study, we characterize PROX1 and CHD7 , two genes we previous...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f0492cb1-83d5-59a6-b273-414ee4e3b9bb
DOI: 10.1101/2022.09.20.507601

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Regulation of cellular LDL uptake by <i>PROX1</i> and <i>CHD7</i>DOI 10.1101/2022.09.20.507601Read

Functional interrogation of cellular Lp(a) uptake by genome-scale CRISPR screeningSemantic proximity Read

Genome-scale CRISPR screening for modifiers of cellular LDL uptakeSemantic proximity Read

Functional interrogation of candidate <i>cis</i> -regulatory elements at the <i>LDLR</i> locusSemantic proximity Read

Systematic elucidation of genetic mechanisms underlying cholesterol uptakeSemantic proximity Read

CSDE1 is a Post-Transcriptional Regulator of the LDL ReceptorSemantic proximity Read

Transgelin: a new gene involved in LDL endocytosis identified by a genome-wide CRISPR-Cas9 screenSemantic proximity Read

Transgelin: A New Gene Involved in LDL Endocytosis Identified by a Genome-wide CRISPR-Cas9 ScreenSemantic proximity Read

Systematic elucidation of genetic mechanisms underlying cholesterol uptakeSemantic proximity Read

Cold shock domain–containing protein E1 is a posttranscriptional regulator of the LDL receptorSemantic proximity Read

iPSC-Derived Endothelial Cells Reveal LDLR Dysfunction and Dysregulated Gene Expression Profiles in Familial HypercholesterolemiaSemantic proximity Read

iPSC-Derived Endothelial Cells Reveals LDLR-Dysfunction and Dysregulated Gene Expression Profiles in Familial HypercholesterolemiaSemantic proximity Read

Precision Regulation of LDL Metabolism: Epigenetic and Genetic Approaches Targeting LDLR, APOB, and PCSK9Semantic proximity Read