Article

The stress-induced transcription factor ATF4 has multiple conserved retrocopies that can alter gene expression

2026-04-02

Abstract excerpt

The cell must defend against various stressors from internal and external sources that disrupt cell homeostasis. The integrated stress response (ISR) is a highly conserved pathway that helps restore this homeostasis through upregulating the transcription factor, ATF4. Despite its importance to cell health and human disease, ATF4 has several duplications in humans that have never been studied. Here, we characteriz...

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Literature Corpus work: e5a75bf5-1d2c-524f-a98c-069eb985145f
DOI: 10.64898/2026.03.31.714484

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