Article

ATF4 Signaling in HIV Infection: Viral Subversion of a Stress Response Transcription Factor

2024-01-23

Abstract excerpt

Cellular Integrated Stress Response (ISR), the mitochondrial Unfolded Protein Response (UP-Rmt) and the IFN signaling are associated with viral infections. The Activating transcription fac-tor 4 (ATF4) plays a pivotal role in these pathways and controls the expression of many genes involved in redox processes, amino acid metabolism, protein misfolding, autophagy and apop-tosis. The precise role of ATF4 during vira...

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Literature Corpus work: 7b4f3def-4feb-5201-ac10-121fa2a8ea77
DOI: 10.20944/preprints202401.1708.v1

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