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Article

Multiple Isolated Transcription Factors Act as Switches and Contribute to Species Uniqueness.

Genes - 29 Sept 2020

Zhao Xin-Wei, Kishino Hirohisa

Abstract excerpt

Mammals have variable numbers (1300-2000) of transcription factors (TFs), but the reasons for this large variation are unclear. To investigate general TF patterns, we de novo identified 156,906 TFs from 96 mammalian species. We identified more than 500 human isolated TFs that are rarely reported in human TF-to-TF networks. Mutations in the genes of these TFs were less lethal than those of connected TFs....

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Identifiers

PMID: 33003522
DOI: 10.3390/genes11101148
PMCID: PMC7600484

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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