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Article

Diversity through duplication: whole-genome sequencing reveals novel gene retrocopies in the human population.

BioEssays : news and reviews in molecular, cellular and developmental biology - 1 May 2014

Richardson Sandra R, Salvador-Palomeque Carmen, Faulkner Geoffrey J

Abstract excerpt

Gene retrocopies are generated by reverse transcription and genomic integration of mRNA. As such, retrocopies present an important exception to the central dogma of molecular biology, and have substantially impacted the functional landscape of the metazoan genome. While an estimated 8,000-17,000 retrocopies exist in the human genome reference sequence, the extent of variation between individuals in terms of...

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PMID: 24615986
DOI: 10.1002/bies.201300181
PMCID: PMC4314676

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Source receipt: pubmed, retrieved 7 Sept 2026.

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