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Primate-specific stress-induced transcription factor POU2F1Z protects human neuronal cells from stress

22 Sept 2021

Abstract excerpt

The emergence of new primate-specific genes is an essential factor in human and primate brain development and functioning. POU2F1/Oct-1 is a transcription regulator in higher eukaryotes which is involved in the regulation of development, differentiation, stress response, and other processes. We have demonstrated that the Tigger2 transposon insertion into the POU2F1 gene which occurred in the primate lineage led...

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PMID: 34552146
DOI: 10.1038/s41598-021-98323-y

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