Article

Genetic overlap between treatment-resistant schizophrenia and smoking initiation

2025-09-27

Abstract excerpt

Early detection of treatment-resistant schizophrenia (TRS) is of substantial clinical importance. While TRS is heritable, the associated genetic variants have been difficult to identify. Cigarette smoking is associated with non-response to antipsychotics, and smoking behavior and schizophrenia have a shared genetic basis. Thus, TRS may also have a shared genetic basis with smoking behavior. Here we aim to identify...

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Literature Corpus work: e58e22b4-66ec-5359-9a36-9a4d06441d2f
DOI: 10.1101/2025.09.24.25336556

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