Article

Genetic overlap between treatment-resistant schizophrenia and smoking initiation

2025-10-25

Abstract excerpt

<title>Abstract</title> <p> Early detection of treatment-resistant schizophrenia (TRS) is of substantial clinical importance. While TRS is heritable, the associated genetic variants have been difficult to identify. Cigarette smoking is associated with non-response to antipsychotics, and smoking behavior and schizophrenia have a shared genetic basis. Thus, TRS may also have a shared genetic basis with smoking beh...

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Literature Corpus work: 9af3c27f-0ac3-5287-8918-f41aa6701336
DOI: 10.21203/rs.3.rs-7768579/v1

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