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Article

Deconstructing the genetic architecture of treatment-resistant schizophrenia in East Asian ancestry.

Asian journal of psychiatry - 1 Dec 2023

Lim Keane, Yee Jie Yin, See Yuen Mei, Ng Boon Tat, Zheng Shushan, Tang Charmaine, Lencz Todd, Lee Jimmy, Lam Max

Abstract excerpt

BACKGROUND: Treatment-resistant schizophrenia (TRS) affects a substantial proportion of patients who do not respond adequately to antipsychotic medications, yet the underlying biological mechanism remains poorly understood. This study investigates the link between the genetic predisposition to schizophrenia and TRS. METHODS: 857 individuals diagnosed with schizophrenia were divided into TRS (n = 142) and non-TRS...

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Source

Identifiers

PMID: 37944474
DOI: 10.1016/j.ajp.2023.103826

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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