Article
A polygenic approach to the association between smoking and schizophrenia.
Addiction biology - 1 Jan 2022
Al-Soufi Laila, Martorell Lourdes, Moltó M Dolores, González-Peñas Javier, García-Portilla Ma Paz, Arrojo Manuel, Rivero Olga, Gutiérrez-Zotes Alfonso, Nácher Juan, Muntané Gerard, Paz Eduardo, Páramo Mario, Bobes Julio, Arango Celso, Sanjuan Julio, Vilella Elisabet, Costas Javier
Abstract excerpt
Smoking prevalence in schizophrenia is considerably larger than in general population, playing an important role in early mortality. We compared the polygenic contribution to smoking in schizophrenic patients and controls to assess if genetic factors may explain the different prevalence. Polygenic risk scores (PRSs) for smoking initiation and four genetically correlated traits were calculated in 1108...
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