Article

Genome-wide association analysis of treatment resistant schizophrenia for variant discovery and polygenic assessment

2024-07-18

Abstract excerpt

<title>Abstract</title> <p>Background Treatment resistant schizophrenia (TRS) is broadly defined as inadequate response to adequate treatment and is associated with a substantial increase in disease burden. Clozapine is the only approved treatment for TRS, showing superior clinical effect on overall symptomatology compared to other drugs, and is the prototype of atypical antipsychotics. Risperidone, another atyp...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8a3eb6fc-98b3-5f79-beb9-d686c9d531b4
DOI: 10.21203/rs.3.rs-4614092/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genome-wide association analysis of treatment resistant schizophrenia for variant discovery and polygenic assessmentDOI 10.21203/rs.3.rs-4614092/v1Read

Genome-wide association analysis of treatment resistant schizophrenia for variant discovery and polygenic assessment.Semantic proximity Read

Treatment-Resistant Schizophrenia, Clozapine Resistance, Genetic Associations, and Implications for Precision Psychiatry: A Scoping ReviewSemantic proximity Read

Interaction Testing and Polygenic Risk Scoring to Estimate the Association of Common Genetic Variants With Treatment Resistance in Schizophrenia.Semantic proximity Read

Polygenic Risk Score for Schizophrenia and Treatment-Resistant Schizophrenia.Semantic proximity Read

A genetic locus in 7p12.2 associated with treatment resistant schizophrenia.Semantic proximity Read

Systems-Level Analysis of Genetic Variants Reveals Functional and Spatiotemporal Context in Treatment-resistant Schizophrenia.Semantic proximity Read

Genetics of schizophrenia.Semantic proximity Read

Polygenic overlap between schizophrenia risk and antipsychotic response: a genomic medicine approach.Semantic proximity Read

Genomic stratification of clozapine prescription patterns using schizophrenia polygenic scoresSemantic proximity Read

Analysis of treatment-resistant schizophrenia and 384 markers from candidate genes.Semantic proximity Read

Novel genomic risk loci and improved prediction for treatment-resistant schizophrenia are revealed by leveraging polygenic overlap with body-mass indexSemantic proximity Read

Genome-wide association analyses of symptom severity among clozapine-treated patients with schizophrenia spectrum disorderSemantic proximity Read