Article

Novel genomic risk loci and improved prediction for treatment-resistant schizophrenia are revealed by leveraging polygenic overlap with body-mass index

2022-10-31

Abstract excerpt

<title>Abstract</title> <p>Treatment resistant schizophrenia (TRS) is characterized by repeated treatment failure with antipsychotics. A recent genome-wide association study (GWAS) of TRS showed a polygenic architecture, but no significant loci were identified. Clozapine is shown to be the superior drug in terms of clinical effect in TRS; at the same time it has a serious side effect profile, including weight gai...

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Literature Corpus work: 92a0a715-015d-536d-8e49-70a0666632e0
DOI: 10.21203/rs.3.rs-2198111/v1

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