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Article

Polygenic overlap with body-mass index improves prediction of treatment-resistant schizophrenia

22 Apr 2023

Abstract excerpt

Treatment resistant schizophrenia (TRS) is characterized by repeated treatment failure with antipsychotics. A recent genome-wide association study (GWAS) of TRS showed a polygenic architecture, but no significant loci were identified. Clozapine is shown to be the superior drug in terms of clinical effect in TRS; at the same time it has a serious side effect profile, including weight gain. Here, we sought to...

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PMID: 37146461
DOI: 10.1016/j.psychres.2023.115217

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