Article
Genetic overlap between treatment-resistant schizophrenia and smoking initiation.
The international journal of neuropsychopharmacology - 1 Jul 2026
Koch Elise, Parker Nadine, Mohammad Helin H, Lenk Hasan Ç, Ystaas Lars A R, Jaholkowski Piotr, Shadrin Alexey A, Frei Oleksandr, Dale Anders M, Djurovic Srdjan, Molden Espen, O'Connell Kevin S, Andreassen Ole A
Abstract excerpt
BACKGROUND: Early detection of treatment-resistant schizophrenia (TRS) is of substantial clinical importance. While TRS is heritable, the associated genetic variants have been difficult to identify. Cigarette smoking is associated with non-response to antipsychotics, and smoking behavior and schizophrenia have a shared genetic basis. Thus, TRS may also have a shared genetic basis with smoking behavior. OBJECTIVE:...
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