Article
Molecular and phenotypic blueprint of the hematopoietic compartment reveals proliferation stress as a driver of age-associated human stem cell dysfunctions
2023-09-16
Abstract excerpt
Hematopoietic stem/progenitor cell (HSPC) aging studies have been associated with myeloid skewing, reduced clonal output, and impaired regenerative capacity, but quantitative immunophenotypic and functional analysis across human aging is lacking. Here, we provide a comprehensive phenotypic, transcriptional, and functional dissection of human hematopoiesis across the lifespan. Although primitive HSPC numbers were s...
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Identifiers and source
- Literature Corpus work
- 6cdb297c-33c5-5ee3-80a8-b3d5bf8579f2
- DOI
- 10.1101/2023.09.15.557553