Article
S/P and T/P phosphorylation is critical for tau neurotoxicity in Drosophila.
Journal of neuroscience research - 1 May 2007
Steinhilb Michelle L, Dias-Santagata Dora, Mulkearns Erin E, Shulman Joshua M, Biernat Jacek, Mandelkow Eva-Maria, Feany Mel B
Abstract excerpt
The microtubule-associated protein tau is hyperphosphorylated abnormally in AD and related neurodegenerative disorders. Many phospho epitopes created by proline directed kinases (SP/TP sites) show relative specificity for disease states. To test whether phosphorylation at the disease-associated SP/TP sites affects tau toxicity in vivo, we expressed a form of tau in Drosophila in which all SP/TP sites are mutated...
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