Article

High-throughput Genome Wide CRISPR Knock Out mechanical sort identifies genes driving metastatic cancer cell softening

2026-02-12

Abstract excerpt

Cell mechanics can serve as an important biomarker for cell state and phenotype, such as metastatic ability. While some molecular mechanisms underlying cell mechanical properties have been investigated through targeted analyses, a genome-wide study of human genes and gene networks that modulate cell biophysical properties has not been attempted. In this work, we combined a microfluidic stiffness-based sorting devi...

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Literature Corpus work: e5655653-5058-5c25-bb25-688b2f6f2d8b
DOI: 10.64898/2026.02.12.705447

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