Article
Predicting cancer cell invasion by single-cell physical phenotyping.
Integrative biology : quantitative biosciences from nano to macro - 23 Apr 2018
Nyberg Kendra D, Bruce Samuel L, Nguyen Angelyn V, Chan Clara K, Gill Navjot K, Kim Tae-Hyung, Sloan Erica K, Rowat Amy C
Abstract excerpt
The physical properties of cells are promising biomarkers for cancer diagnosis and prognosis. Here we determine the physical phenotypes that best distinguish human cancer cell lines, and their relationship to cell invasion. We use the high throughput, single-cell microfluidic method, quantitative deformability cytometry (q-DC), to measure six physical phenotypes including elastic modulus, cell fluidity, transit...
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