Article

Nicotinamide riboside alleviates Parkinson’s disease symptoms but downregulates dopamine metabolism upon lactacystin-induced proteostasis failure

2021-03-12

Abstract excerpt

Activation of mitochondrial metabolism and proteostasis with the NAD + precursor nicotinamide riboside (NR) has emerged as a potential therapeutic approach for neurodegenerative disorders including Parkinson’s disease (PD). However, despite recently started clinical trials, studies on NR in animal models of PD are scarce. In this study, we investigated the effect of NR in multiple models of PD. In transgenic C....

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Literature Corpus work: e54c3347-a7e3-58c0-85fb-6b3927acf9a5
DOI: 10.1101/2021.03.12.435062

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