Article
Rosmarinic acid ameliorated oxidative stress, neuronal injuries, and mitochondrial dysfunctions mediated by polyglutamine and ɑ-synuclein in Caenorhabditis elegans models
2023-05-04
Abstract excerpt
<title>Abstract</title> <p>Numerous natural antioxidants have been developed into agents for neurodegenerative diseases (NDs) treatment. Rosmarinic acid (RA), an excellent antioxidant, exhibits neuroprotective activity, but its anti-NDs efficacy still reminds puzzled. Here, <italic>Caenorhabditis elegans</italic> models were employed to systematically reveal RA-mediated mechanisms in delaying NDs from diverse fac...
Topics
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- Alzheimer's disease research and treatments
- Cholinesterase and Neurodegenerative Diseases
- Dopaminergic Neurons
- Genetics, Aging, and Longevity in Model Organisms
- Hydrogen Peroxide
- Intercellular Signaling Peptides and Proteins
- Medicinal Plants and Neuroprotection
- Parkinson's Disease Mechanisms and Treatments
Identifiers and source
- Literature Corpus work
- e455972f-a6f6-518e-81ab-5e810f979c64
- DOI
- 10.21203/rs.3.rs-2868747/v1
